2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W775348
    Tetrahydrocannabiphorol 54763-99-4
    Tetrahydrocannabiphorol (THCP) is a phytocannabinoid.
    Tetrahydrocannabiphorol
  • HY-W777166
    Aprepitant-13C2,d2 (Major) 1217676-37-3
    Aprepitant-13C2,d2 (Major) (MK-0869-13C2,d2) is 13C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
    Aprepitant-13C2,d2 (Major)
  • HY-W777345
    Moperone 1050-79-9
    Moperone (R 1658) is an antagonist for D2 dopamine receptor and D3 dopamine receptor, with IC50 of 1.0 nM and 1.0 nM.
    Moperone
  • HY-W779640
    25I-NBOMe 4-methoxy isomer hydrochloride 1566571-64-9
    25I-NBOMe 4-methoxy isomer hydrochloride is an isomer of 25I-NBOMe. 25I-NBOMe is an agonist for 5-HT2A, that binds to rat 5-HT2A and human 5-HT2A with Ki of 0.087 nM and 0.044 nM.
    25I-NBOMe 4-methoxy isomer hydrochloride
  • HY-W779800
    D-α-Hydroxyglutaric acid-13C5 disodium 1648909-80-1
    D-α-Hydroxyglutaric acid-13C5 disodium is the 13C-labeled D-α-Hydroxyglutaric acid (HY-113038). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified.
    D-α-Hydroxyglutaric acid-13C5 disodium
  • HY-W781963
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one 62659-65-8
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one is a metabolite of Flubromazepam.
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
  • HY-W783639
    Bzo-poxizid 1048973-64-3
    Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance.
    Bzo-poxizid
  • HY-W792513
    WAY-620147 515866-67-8 ≥98.0%
    WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide derivative that inhibits monoamine oxidase (Monoamine Oxidase). WAY-620147 inhibits MAO-A and MAO-B with IC50s of 26 μM and 55 μM, respectively.
    WAY-620147
  • HY-W835723
    1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one 221696-69-1
    1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one is a phenolic compound derived from Dracaena cochinchinensis that exhibits antioxidant, antimicrobial, antiviral, hemostatic, antithrombotic, anti-inflammatory activities, and protects myocardial cells.
    1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
  • HY-W839261
    Tyrosine kinase-IN-9 370854-75-4
    Tyrosine kinase-IN-9 (Compound B) is the inhibitor for c-Abl. Tyrosine kinase-IN-9 can be used in research of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease.
    Tyrosine kinase-IN-9
  • HY-W839383
    2,3-Diphenylquinoxaline-6-sulphonamide 380347-87-5
    2,3-Diphenylquinoxaline-6-sulphonamide exhibits potential antibacterial, analgesic, and anti-inflammatory properties.
    2,3-Diphenylquinoxaline-6-sulphonamide
  • HY-W840382
    CK1δ-IN-8 438018-70-3
    CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor that can be used in Alzheimer's disease research.
    CK1δ-IN-8
  • HY-W844543
    Protein kinase inhibitor 12 721964-48-3
    Protein Kinase Inhibitor 12 (compound 1-91) is a triazolopyridazine derivative and protein kinase inhibitor that can be utilized in research related to diseases associated with protein kinases.
    Protein kinase inhibitor 12
  • HY-W922811
    DL-Willardiine 19772-76-0
    DL-Willardiine is an AMPA antagonist with an IC50 of 2 μM. DL-Willardiine can be utilized in psychotropic cccccc research.
    DL-Willardiine
  • HY-W931056
    AMG-628 862269-93-0
    AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats.
    AMG-628
  • HY-W966282
    Aplindore 189681-70-7
    Aplindore (DAB-452) is a potent agonist of the dopamine D2 receptor, with the pKi of 9.1. Aplindore plays an important role in Parkinson's disease research.
    Aplindore
  • HY-W975966
    CPDT 14085-33-7
    CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro[2].
    CPDT
  • HY-100369AR
    DMCM hydrochloride (Standard) 1215833-62-7
    DMCM (hydrochloride) (Standard) is the analytical standard of DMCM (hydrochloride). This product is intended for research and analytical applications. DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 ?receptors, respectively.
    DMCM hydrochloride (Standard)
  • HY-100583AR
    (±)-Equol (Standard) 94105-90-5
    (±)-Equol (Standard) is the analytical standard of (±)-Equol. This product is intended for research and analytical applications. (±)-Equol is the racemate of equol. (±)-equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.
    (±)-Equol (Standard)
  • HY-100714CR
    DL-AP5 sodium (Standard) 1303993-72-7
    DL-AP5 (sodium) (Standard) is the analytical standard of DL-AP5 (sodium). This product is intended for research and analytical applications. DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina.
    DL-AP5 sodium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity